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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Related Experiment Video

Updated: Jun 19, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Advances in Dynamic/Adaptive Supramolecular Self-Assembly: From Molecular Design to Stimuli-Responsive Control.

Yanqiu Wang1, Xiaoran Yang1, Xiande Shen1

  • 1Engineering Research Center of Optoelectronic Functional Materials, School of Materials Science and Engineering, Ministry of Education, Changchun University of Science and Technology, Changchun, China.

Macromolecular Rapid Communications
|June 18, 2026
PubMed
Summary

Dynamic/adaptive self-assembly systems, utilizing reversible bonds, offer tunable functions in response to external stimuli. These advanced materials hold promise for smart devices and precision medicine applications.

Keywords:
dynamic/adaptive self‐assemblyexternal stimulismart responsivestructural dynamic regulation

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science

Background:

  • Dynamic/adaptive self-assembled systems are crucial in supramolecular chemistry and materials science.
  • These systems use reversible bonds to control interactions and functions via external stimuli.

Purpose of the Study:

  • To systematically review research progress in dynamic/adaptive self-assembly systems.
  • To focus on design principles, regulatory properties, and applications of these systems.

Main Methods:

  • Review of design principles for organic molecules and biomacromolecules as building blocks.
  • Discussion of dynamic structural regulation by various external stimuli.
  • Exploration of computational and theoretical approaches for system analysis.

Main Results:

  • Self-assembled nanostructures exhibit stimuli-responsiveness and environmental adaptability.
  • Applications span smart materials, precision biomedicine, and micro/nano manufacturing.
  • Key building blocks and regulatory mechanisms are analyzed.

Conclusions:

  • Dynamic/adaptive self-assembly systems offer significant potential in diverse scientific and technological fields.
  • Computational methods are vital for understanding and predicting system behavior.
  • The review provides guidance for precise design and optimization of these systems.