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Updated: Jun 19, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Solvent-Controlled Divergent Catalysis toward the Synthesis of Fluvastatin Analogs
Athira Parammal1, Arup Jyoti Das1, Maheshwar Sethi1
1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India.
Abstract:
A solvent-controlled, divergent Rh(III)-catalyzed strategy enables the synthesis of structurally diverse fluvastatin analogs. Enantioenriched α,β-unsaturated ketones derived from 2-deoxy-d-ribose undergo selective C2-H functionalization of indoles, affording olefination or hydroarylation products under complementary conditions. The method shows broad scope and functional group tolerance. Mechanistic studies indicate a solvent-driven switch between β-hydride elimination and protodemetalation, providing rapid access to both enantiomeric series of fluvastatin-inspired scaffolds.
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