Related Experiment Video

Updated: Jun 19, 2026

Microfluidic Mixers for Studying Protein Folding
12:42

Microfluidic Mixers for Studying Protein Folding

Published on: April 10, 2012

Signatures of protein fold switching in the unfolded state

David Wang1, Robert B Best2

  • 1Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.

Biophysical Journal
|June 18, 2026
PubMed
Summary

Researchers analyzed protein folding using cooperativity in unfolded states. They found that fold-switching proteins exhibit distinct cooperative contact networks, suggesting these signatures are present even before folding.

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