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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

Updated: Jun 19, 2026

Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers
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Published on: January 24, 2025

90Y Radioactive Microsphere and its In Situ Labeling Strategy in Biological Systems for Real-Time Distribution

Xinmiao Lu1, Yue Li1, Hanyu Bai1

  • 1Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Advanced Healthcare Materials
|June 18, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a novel imaging method for Yttrium-90 selective internal radiotherapy (90Y-SIRT) using streptavidin-decorated microspheres and Gallium-68 labeled biotin. The new technique allows for precise in situ imaging of microsphere distribution, enhancing treatment accuracy and efficacy.

Keywords:
90Y‐SIRTbioorthogonal chemistryin situ labellingmolecular imaging

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Area of Science:

  • Radiochemistry and Nuclear Medicine
  • Biomaterials and Nanotechnology
  • Oncology and Therapeutics

Background:

  • Molecular imaging is crucial for Yttrium-90 selective internal radiotherapy (90Y-SIRT), but current methods face limitations.
  • Pre-operative simulation imaging with 99mTc-MAA has inherent differences from therapeutic microspheres.
  • Post-operative imaging using 90Y bremsstrahlung SPECT/PET is hampered by low positron yield or inherent limitations.

Purpose of the Study:

  • To develop a novel Yttrium-90 microsphere and an improved imaging protocol for 90Y-SIRT.
  • To overcome the critical imaging limitations of conventional 90Y-SIRT.
  • To enable robust self-reporting of therapeutic microsphere distribution via PET imaging.

Main Methods:

  • Synthesized streptavidin-decorated polystyrene microspheres (SPS) as the embolic agent.
  • Developed a complementary imaging pair: 68Ga-labeled biotin ([68Ga]Ga-Biotin) for in situ labeling.
  • Administered [68Ga]Ga-Biotin intravenously after intra-arterial embolization of 90Y-SPS for PET imaging.

Main Results:

  • SPS demonstrated excellent 90Y capture capacity and stability in vitro.
  • The in situ labeling method provided high-contrast PET imaging of microsphere distribution.
  • Calculated hepatic-pulmonary and hepatic-abdominal shunts accurately.
  • Peritumorally loaded 90Y-SPS showed significant antitumor effects (nearly 90% inhibition) with low toxicity.

Conclusions:

  • The developed bioorthogonal in situ labeling platform overcomes critical imaging limitations in 90Y-SIRT.
  • This method provides a robust way to visualize therapeutic microsphere distribution using PET imaging.
  • The approach maintains strong antitumor effects while improving treatment monitoring and accuracy.