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  1. Home
  3. Gulp1 In Ovarian Cancer: Expression, Biological Function, And Clinical Significance.
  1. Home
  3. Gulp1 In Ovarian Cancer: Expression, Biological Function, And Clinical Significance.

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GULP1 in Ovarian Cancer: Expression, Biological Function, and Clinical Significance.

Zongzong Sun1, Xinjun Hu2, Di Huang3

  • 1Department of Obstetrics and Gynaecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Current Gene Therapy
|June 18, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

GULP1 is downregulated in ovarian cancer (OVCA), promoting tumor progression and immune evasion. Targeting GULP1 with LFM-A13 shows potential for OVCA precision therapy, but requires clinical validation.

Keywords:
GULP1Ovarian cancerbiomarkerimmune evasiontargeted therapy.

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Published on: August 28, 2012

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genomics

Background:

  • GULP1 acts as an engulfment adapter for apoptotic clearance.
  • Its role in ovarian cancer (OVCA) progression and its association with the tumor microenvironment (TME) are largely unknown.

Purpose of the Study:

  • To investigate the role of GULP1 in OVCA.
  • To analyze its correlation with immune evasion and key signaling pathways.
  • To identify potential therapeutic strategies targeting GULP1.

Main Methods:

  • Analysis of GULP1 expression and copy number variations (CNVs) in TCGA-OVCA and GEPIA datasets.
  • Gene set enrichment analysis (GSEA) and immune infiltration assessment.
  • Molecular docking and cellular assays to evaluate drug binding and GULP1 function.

Main Results:

  • GULP1 was found to be downregulated in OVCA, correlating with advanced stages and immune evasion.
  • GULP1 expression was linked to hypoxia, EMT, angiogenesis, and TGFβ signaling.
  • LFM-A13 showed binding affinity to GULP1, and GULP1 modulation affected OVCA cell migration and invasion.

Conclusions:

  • GULP1 serves as a novel biomarker for OVCA progression and immune escape.
  • Targeting GULP1 with LFM-A13 presents a potential precision therapy strategy for OVCA.
  • Further clinical validation is necessary to confirm the efficacy of LFM-A13.