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Updated: Jun 19, 2026

Three-dimensional Optical-resolution Photoacoustic Microscopy
Published on: May 3, 2011
Geometry-dependent reachability, homogenization, and redundancy in multi-view photoacoustic illumination
1Inner Mongolia Key Laboratory of Biophysics and Bioinformatics, School of Physical Science and Technology, Inner Mongolia University, No.235 West College Road, Saihan District, Hohhot, Inner Mongolia, 010021, China.
None:
In deep scattering tissue, vascular geometry strongly modulates the optical fluence field, thereby complicating quantitative photoacoustic imaging and the assessment of multi-view illumination. This study establishes a geometry-consistent basis for comparing multi-view photoacoustic illumination across complex vascular geometries under a unified fluence-side criterion. Illumination directions are drawn from a fixed candidate view pool and accumulated as a stable prefix, while the unified reachability threshold is calibrated once from a baseline reference view and then applied to all geometries and all view counts. This protocol enables direct comparison of union-reachability coverage Ω reach , fluence nonuniformity V G , low-fluence-tail response, and view-response redundancy. Monte Carlo simulations on five aneurysm-like vascular geometries show that Ω reach increases rapidly at small view numbers and then approaches geometry-dependent saturation levels of approximately 0.514 - 0.553, a behavior preserved under moderate optical-transport perturbations and controlled variations in thresholding, photon number, view ordering, and view selection. Matched-coverage analysis further shows that comparable reachability does not imply comparable homogenization, because V G and the local response coefficient ηG * remain geometry dependent within the same coverage window. Spectral analysis of the view-response matrix reveals geometry-constrained effective low dimensionality, with terminal Neff values of approximately 4.2 - 7.4, far below the nominal number of accumulated views. These results identify reachable-domain expansion, fluence homogenization, and response redundancy as coupled but non-equivalent aspects of multi-view photoacoustic illumination, providing physically interpretable criteria for assessing view accumulation in complex vascular geometries.
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