Related Experiment Video
Updated: Jun 19, 2026
06:15
Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
Efficacy of Less Invasive Surfactant Administration (LISA) in Preterm Neonates With Respiratory Distress Syndrome: A
Xuezheng Sun1, Shaked Yarza1, Yuting Kuang2
1Chiesi USA Inc, Cary, NC, USA.
Sage Open Pediatrics
|June 18, 2026
Summary
Less invasive surfactant administration (LISA) improves outcomes for preterm infants with respiratory distress syndrome (RDS). Greater benefits were seen in infants born earlier and those with antenatal steroid exposure.
Area of Science:
- Neonatal Medicine
- Pediatric Pulmonology
- Critical Care
Background:
- Respiratory distress syndrome (RDS) affects preterm infants.
- Less invasive surfactant administration (LISA) is a common treatment.
- Treatment effect variations in subgroups require clarification.
Purpose of the Study:
- Systematically review and meta-analyze trials comparing LISA and INtubation-SURfactant-Extubation (INSURE).
- Evaluate treatment effects across subgroups: gestational age, surfactant type, antenatal corticosteroids, and sedation.
Main Methods:
- Systematic review and meta-analysis of randomized controlled trials (2010-2024).
- Included 21 trials with 2656 preterm infants.
- Used random-effects models and subgroup analyses.
Main Results:
- LISA reduced odds of bronchopulmonary dysplasia, death, and severe intraventricular hemorrhage.
- LISA lowered need for intubation or mechanical ventilation.
- Benefits were greater in infants ≤34 weeks and with higher antenatal steroid exposure.
Conclusions:
- LISA improves key outcomes compared to INSURE in preterm infants with RDS.
- LISA may offer enhanced benefits for specific clinical subgroups.
Related Concept Videos
01:05Breathing
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
01:29Acute Respiratory Failure-V
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
01:29Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...