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Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

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Related Experiment Video

Updated: Jun 19, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
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Published on: August 11, 2019

Acute hyperexcitability differentially affects hippocampal neurogenesis features and spatial memory.

Diana López-Ibarra1, Andrea Aguilar-Arredondo2,3, Verónica Gaytan-Zeron1

  • 1Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, UNAM, Mexico City, Mexico.

Frontiers in Cellular Neuroscience
|June 18, 2026
PubMed
Summary

Epileptic seizures alter adult hippocampal neurogenesis (AHN). Varying seizure severity differentially impacts brain cell development and spatial memory, revealing qualitative effects of hyperexcitability on cognition.

Keywords:
acute seizuresadult hippocampal neurogenesisadult hippocampusbehaviorbrain damagebrain plasticitycontextual fear conditioning and memory (CFC)dentate gyrus

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Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
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Published on: May 12, 2015

Related Experiment Videos

Last Updated: Jun 19, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Cell Biology

Background:

  • Epileptic seizures are known to disrupt adult hippocampal neurogenesis (AHN).
  • The precise impact of varying seizure intensities on AHN and cognitive functions remains incompletely understood.

Purpose of the Study:

  • To investigate how different seizure severities affect adult hippocampal neurogenesis and associated memory functions.
  • To examine the morphological and synaptic changes in adult-born granule cells (abGCs) following acute hyperexcitability.

Main Methods:

  • Administered low (5 mg/kg) or high (25 mg/kg) dose kainic acid (KA) to induce varying seizure severity in mice.
  • Utilized genetic labeling to track progenitor cells and their progeny in the dentate gyrus.
  • Recorded EEG, assessed spatial and contextual fear memory, and analyzed abGCs 32 days post-treatment.

Main Results:

  • High-dose KA induced more severe seizures, increased mature abGCs with altered positioning, and elevated dendritic spine density.
  • Low-dose KA resulted in presynaptic bouton enlargement in abGCs.
  • Both doses impaired spatial recognition memory but preserved contextual fear memory.

Conclusions:

  • Acute seizure severity differentially modulates the morphological and synaptic characteristics of adult-born granule cells.
  • Hyperexcitability selectively disrupts hippocampal-dependent spatial memory.
  • Seizure severity exerts qualitative effects on both neurogenesis and cognitive function.