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Related Experiment Video

Updated: Jun 19, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Application of Management, Outcome, Risk, and Expectation Classification for Antenatally Suspected Structural

Sunita Singh1, Divya Prakash1, Nitin Kumar Borkar2

  • 1Department of Paediatric Surgery, All India Institute of Medical Sciences, Raebareli, Uttar Pradesh, India.

Journal of Indian Association of Pediatric Surgeons
|June 18, 2026
PubMed
Summary

The Management, Outcome, Risk, and Expectation (MORE) framework effectively assessed antenatally suspected structural congenital anomalies. This approach optimized prognostication and supported parental decision-making for improved neonatal care.

Keywords:
Antenatally suspected structural congenital disabilitiesManagementOutcomeRiskand Expectationbirth defectsclassificationcleft palatecongenital anomaliescongenital disabilitiescongenital malformationsfolic acidgenetic counselingmeningomyeloceleneural tube defectspediatric surgeonspina bifida

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Last Updated: Jun 19, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Area of Science:

  • Perinatal Medicine
  • Medical Genetics
  • Fetal Medicine

Background:

  • Antenatally suspected structural congenital anomalies (ASSCAs) present complex management challenges.
  • Accurate prognostication and informed parental decision-making are crucial for these cases.

Purpose of the Study:

  • To evaluate the utility of the Management, Outcome, Risk, and Expectation (MORE) framework in assessing ASSCAs.
  • To analyze the outcomes, risks, and parental expectations associated with ASSCAs.

Main Methods:

  • Retrospective analysis of 261 pregnancies with ASSCAs from a multidisciplinary clinic.
  • Application of the MORE framework to categorize management, outcomes, risk factors, and parental expectations.

Main Results:

  • Structural anomalies were identified between 12 and 33 weeks gestation, with 52.8% detected before 20 weeks.
  • Outcomes varied, with significant proportions requiring neonatal surgery (24.5%) or resulting in neonatal death (3.1%).
  • Parental expectations were predominantly aligned with realistic outcomes (84.3%).

Conclusions:

  • The MORE framework aids in optimizing prognostication and supporting evidence-based parental decision-making for ASSCAs.
  • Challenges in uniform implementation include attrition, limited diagnostic infrastructure, and socioeconomic factors.