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Performance of Survival Prediction Tools in Patients With Gastrointestinal Stromal Tumors: A Systematic Review and
Alice Zhu1, Chloe Wong1, Neill K J Adhikari2,3,4
1Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Abstract:
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. We conducted a systematic review and meta-analysis of studies that developed, validated, or updated clinical prognostic tools to predict survival in adults with primary GIST, identifying 47 eligible studies (38 development and 9 validation studies). Meta-analyses were performed to assess performance in external validation cohorts. The MSKCC nomogram was most frequently validated, with a pooled C-statistic of 0.78 for recurrence-free survival.
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