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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
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Published on: November 7, 2017

Maternal Mortality and Cardio-Kidney-Metabolic Risk Factors Across High-Income Countries.

Emily Littman1, Yaa Adoma Kwapong2, Amelia S Wallace3

  • 1Department of Internal Medicine, Johns Hopkins University College of Medicine, Baltimore, Maryland, USA.

JACC. Advances
|June 18, 2026
PubMed
Summary
This summary is machine-generated.

US women of reproductive age experience higher rates of cardiovascular disease (CVD), cardio-kidney-metabolic (CKM) risk factors, and maternal mortality compared to other high-income nations. Early screening and management of CVD and CKM factors are crucial priorities.

Keywords:
cardiovascular diseasescardiovascular-kidney-metabolic healthglobal burden of diseasehigh-income countriesmaternal mortalitywomen’s health

Related Experiment Videos

Last Updated: Jun 19, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

Area of Science:

  • Public Health
  • Cardiology
  • Obstetrics & Gynecology

Background:

  • Cardiovascular disease (CVD) is a leading cause of death globally and a significant contributor to maternal mortality in the U.S.
  • Women of reproductive age are particularly vulnerable to CVD and related risk factors.

Purpose of the Study:

  • To compare the prevalence and trends of CVD, cardio-kidney-metabolic (CKM) risk factors, and maternal mortality in U.S. women of reproductive age (15-49 years) against other high-income countries.
  • To identify disparities in CVD and CKM risk factor burden and their impact on maternal health outcomes.

Main Methods:

  • Utilized Global Burden of Disease 2023 data spanning from 2003 to 2023.
  • Evaluated CVD prevalence, disability-adjusted life years (DALYs), CKM risk factors (BMI, fasting plasma glucose, systolic blood pressure), and maternal mortality rates, including those linked to hypertensive disorders of pregnancy.

Main Results:

  • Despite a decline in CVD prevalence and DALYs, the U.S. burden remained higher than in comparable nations.
  • DALY rates linked to CKM risk factors were significantly higher in the U.S. (4-fold for BMI, 3-fold for glucose, 2-fold for blood pressure).
  • In 2023, the U.S. exhibited high maternal mortality rates, particularly those associated with hypertensive disorders of pregnancy, compared to other high-income countries.

Conclusions:

  • U.S. women of reproductive age face a disproportionate burden of CVD, CKM risk factors, and maternal mortality.
  • Urgent integration of early CVD and CKM screening and management into U.S. healthcare is a national priority.