Related Experiment Video
Updated: Jun 19, 2026
03:10
A Rat Model of Compound Acne
Published on: November 1, 2024
Hormonal acne therapies in pediatrics
Carla Torres-Zegarra1, Sofia Guelfand Warnken
1Department of Dermatology, University of Colorado School of Medicine, Denver, Aurora, USA.
Current Opinion in Pediatrics
|June 18, 2026
Summary
Acne vulgaris, a common adolescent skin condition, involves multiple factors including hormones. Hormonal therapies are increasingly recognized as a key treatment for selected patients with this chronic inflammatory condition.
Area of Science:
- Dermatology
- Endocrinology
- Adolescent Medicine
Background:
- Acne vulgaris affects up to 85% of adolescents (12-24 years).
- This inflammatory skin condition significantly impacts psychological well-being and quality of life.
- Acne's pathogenesis is multifactorial, involving follicular hyperkeratinization, sebum production, Cutibacterium acnes, and inflammation.
Purpose of the Study:
- To explore the role of hormonal influences in acne pathogenesis.
- To highlight the significance of hormonal therapies in acne management.
Main Methods:
- Review of acne pathogenesis, emphasizing hormonal factors.
- Analysis of clinical features associated with hormonal influences.
- Evaluation of hormonal therapies as a treatment option.
Main Results:
- Hormonal factors, particularly androgens, are central to acne development.
- Specific clinical presentations, like lower face acne and menstrual cycle flares, suggest prominent hormonal involvement.
- Hormonal therapies are effective for selected adolescent patients.
Conclusions:
- Acne is a chronic inflammatory condition with significant hormonal contributions.
- Hormonal therapies are an important treatment modality for specific acne cases in adolescents.
Related Concept Videos
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms: