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Updated: Jun 19, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Published on: January 7, 2019

Extreme Nanoconfinement Dramatically Enhances Small Molecule Solubility in Nonpolar Polymers.

Kaiwen Wang1, Joseph Tapia2, Tian Ren1

  • 1Department of Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.

ACS Nano
|June 18, 2026
PubMed
Summary
This summary is machine-generated.

Confinement dramatically increases gas solubility in polymers within nanoparticle pores, with pore size being the key factor. This finding has implications for gas separation technologies and polymer upcycling.

Keywords:
capillary rise infiltration (CaRI)gas separation membranesgas sorptionpolymer upcyclingquartz crystal microbalance (QCM)silica nanopores

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Last Updated: Jun 19, 2026

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Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

Area of Science:

  • Polymer Physics
  • Materials Science
  • Nanotechnology

Background:

  • Understanding gas solubility in confined polymers is crucial for advancing gas barrier materials, separation technologies, and polymer upcycling.
  • Existing knowledge gaps hinder the optimization of polymer-based systems for gas interactions in confined environments.

Purpose of the Study:

  • To investigate the solubility of gases (methanol and n-hexane) in polymers (polystyrene and low-density polyethylene) confined within silica nanoparticle packings.
  • To determine the primary factors influencing gas solubility enhancement under nanoconfinement.

Main Methods:

  • Polymers were infiltrated into silica nanoparticle packings using capillary rise infiltration.
  • Gas solubility in confined polymers was quantified using a quartz crystal microbalance.
  • Atomistic simulations were employed to elucidate the underlying mechanisms of solubility enhancement.

Main Results:

  • Confinement within nanoparticle pores resulted in a 10- to ~100-fold increase in gas solubility compared to bulk polymers.
  • Pore size was identified as the dominant factor influencing solubility enhancement; polymer molecular weight and nanoparticle surface chemistry had minimal impact.
  • Atomistic simulations indicated that both confinement and surface-polymer interactions contribute to enhanced solubility, modulated by polymer packing.

Conclusions:

  • Geometric nanoconfinement is the principal driver of gas solubility enhancement in polymers within nanoporous materials.
  • Changes in polymer segment arrangement due to confinement are responsible for the observed solubility trends.
  • Confined polymers offer significant potential for engineering advanced separation membranes and improving polymer upcycling processes.