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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Introduction Cardiac Emergencies01:30

Introduction Cardiac Emergencies

Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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Updated: Jun 19, 2026

Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

Cardiac Rupture Complicating Acute and Subacute Myocardial Infarction at Forensic Autopsy.

Megan Dukes1, Alison Krywanczyk2

  • 1Cleveland Clinic Foundation.

The American Journal of Forensic Medicine and Pathology
|June 18, 2026
PubMed
Summary
This summary is machine-generated.

Cardiac rupture following myocardial infarction is a severe complication. This autopsy study found older, White patients with fewer signs of heart disease were at higher risk, with longer symptom duration.

Keywords:
autopsyforensic pathologymyocardial infarctionrisk factorrupture

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A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
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Published on: July 17, 2012

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Last Updated: Jun 19, 2026

Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

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Published on: December 11, 2016

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
13:42

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion

Published on: July 17, 2012

Area of Science:

  • Cardiovascular Pathology
  • Forensic Medicine

Background:

  • Cardiac rupture is a feared complication of myocardial infarction, despite decreased incidence.
  • Early identification of high-risk individuals and modifiable risk factors is crucial for improving outcomes.

Purpose of the Study:

  • To identify risk factors and characteristics of patients experiencing cardiac rupture post-myocardial infarction using autopsy data.
  • To compare rupture cases with non-rupture cases to understand differences in patient demographics and pathology.

Main Methods:

  • Retrospective review of 288 autopsies for myocardial infarction cases between 2010 and 2024.
  • Comparison of demographic, clinical history, and autopsy findings between cardiac rupture and non-rupture groups.

Main Results:

  • 22% of myocardial infarction cases (63/288) were complicated by cardiac rupture.
  • Patients with cardiac rupture were more likely to be White, older, and less likely to show cardiomegaly, myocardial fibrosis, or have a history of diabetes mellitus.
  • The study group exhibited a higher cardiac rupture rate and longer preceding symptom duration than previously reported.

Conclusions:

  • Cardiac rupture in myocardial infarction may present differently than previously understood, with specific demographic and pathological profiles.
  • Further research is needed to elucidate the mechanisms and refine early detection strategies for cardiac rupture.