Chest Pain With Immune Checkpoint Inhibitor Therapy: Harnessing the Power of Multimodality Imaging
Rukmini Roy1, Linda Liu1, Huihua Li2
1University of Chicago Medical Center, Chicago, Illinois, USA.
JACC. Case Reports
|June 18, 2026
Summary
Immune checkpoint inhibitors (ICIs) can cause rare but serious pericarditis in lung cancer patients. High clinical suspicion and serial imaging are crucial for diagnosing this cardiovascular immune-related adverse event.
Area of Science:
- Cardiology
- Oncology
- Immunology
Background:
- Immune checkpoint inhibitors (ICIs) like pembrolizumab enhance outcomes in metastatic non-small-cell lung cancer.
- Cardiovascular immune-related adverse events, including pericarditis, are uncommon but serious complications of ICIs.
- Pericarditis is often underrecognized in patients receiving ICI therapy.
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