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Photoluminescence: Applications

Photoluminescence: Applications

Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...

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A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence (FUEL)

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Published on: May 23, 2014

BNCT Plus Luminescence: New Paradigm for Boron-Containing Drug Design.

Xin Liu¹, Deshuang Tu², Chang-Sheng Lu³

¹State Key Laboratory of Coordination Chemistry, School of Chemistry, Nanjing University, Nanjing, China.

Handbook of Experimental Pharmacology

|June 18, 2026

Summary

Developing advanced boron-containing drugs with fluorescence imaging capabilities is key for Boron Neutron Capture Therapy (BNCT). This innovation allows real-time monitoring of drug distribution, improving cancer treatment precision.

Keywords:

Boron neutron capture therapy Carboranes Fluorescence imaging Luminescence

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Area of Science:

Oncology
Medical Imaging
Materials Science

Background:

Boron Neutron Capture Therapy (BNCT) is an advanced cancer treatment requiring effective boron delivery agents.
Current boron-containing drugs for BNCT show promise in targeting various cancers but lack in vivo distribution monitoring.
Precise neutron irradiation in BNCT is hindered by the inability to track drug distribution within the body.

Purpose of the Study:

To explore the design and application of photo-functional boron-containing drugs for integrated diagnosis and BNCT.
To address the challenge of monitoring boron drug distribution in vivo using fluorescence imaging.
To highlight the potential of luminescent boron-containing drugs for enhanced BNCT efficacy.

Main Methods:

Reviewing molecular design strategies for boron-containing drugs with fluorescence imaging capabilities.
Discussing the integration of fluorescence imaging techniques (near-infrared, two-photon absorption, fluorescence lifetime imaging) with boron drug development.
Analyzing the application of these advanced drugs in preclinical cancer models.

Main Results:

Development of novel boron-containing drugs incorporating fluorescence imaging modalities.
Demonstration of precise spatial and concentration mapping of boron drugs via fluorescence imaging.
Successful application of these integrated diagnostic and therapeutic agents in BNCT research.

Conclusions:

Fluorescence-imaging boron-containing drugs offer a promising solution for real-time monitoring in BNCT.
These advanced drugs have the potential to significantly improve the precision and effectiveness of BNCT for various cancers.
Ongoing research in this area is crucial for the future clinical translation of BNCT.