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Updated: Jun 19, 2026

Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging
Published on: December 9, 2021
Black-blood dynamic contrast-enhanced MRI of abdominal aortic aneurysms
Wilhelm Stehling1,2, Eva Aalbregt3,4,5, Myrte Wennen3
1Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands. w.a.stehling@amsterdamumc.nl.
Purpose:
To develop a dynamic contrast-enhanced (DCE) MRI protocol for imaging the aortic wall of abdominal aortic aneurysms (AAAs), and to investigate the repeatability and clinical correlation of novel biomarkers for rupture risk assessment.
Methods:
A dedicated DCE protocol with black-blood contrast was applied to 20 patients with AAA, of which 16 underwent a second scan 6 months later. Semiquantitative DCE-derived parameters in the aneurysm wall were calculated, assessed for test-retest repeatability using within-subject coefficient of variation (wCV), and correlated with clinical measures (aneurysm diameter and growth rate) using Spearman's rank correlation.
Results:
The developed protocol allows for accurate delineation of the aortic wall and calculation of semiquantitative DCE-derived parameters. The maximum enhancement (ME) and area under the curve (AUC) demonstrated good stability with wCVs of 14% and 18%, respectively. No significant correlations were found between DCE-derived parameters and clinical measures.
Conclusion:
The derived DCE protocol enables repeatable assessment of semiquantitative parameters of the aortic wall in AAA patients. No correlation was found between DCE-derived parameters and clinical markers of aneurysm progression.
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