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Updated: Jun 19, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
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Ceftriaxone-Resistant Enteric Fever Outbreak in Children From Thane: A Multicenter Prospective Study.

Sudhir Sane1, Sunil Junagade2, Mahesh Mohite3

  • 1Department of Pediatrics, Jupiter Lifeline Hospitals, Off Eastern Express Highway, Thane West, Thane, Maharashtra, 400602, India. sudhirs4@hotmail.com.

Indian Pediatrics
|June 18, 2026
PubMed
Summary

A study in India found ceftriaxone-resistant enteric fever, with tanker water linked to resistance. This highlights a critical public health issue in Thane, Maharashtra.

Keywords:
Antibiotic resistanceTanker waterTyphoid fever

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Area of Science:

  • Infectious Disease Epidemiology
  • Antimicrobial Resistance Surveillance

Background:

  • Enteric fever outbreaks pose a significant public health challenge, particularly in resource-limited settings.
  • Emerging antimicrobial resistance, including resistance to critical antibiotics like ceftriaxone, complicates treatment and increases morbidity.

Purpose of the Study:

  • To investigate an outbreak of enteric fever in Thane, Maharashtra, India.
  • To determine the prevalence of ceftriaxone resistance among enteric fever cases.
  • To identify potential risk factors associated with ceftriaxone resistance.

Main Methods:

  • Prospective study design.
  • Culture-proven diagnosis of enteric fever.
  • Antimicrobial susceptibility testing, focusing on ceftriaxone resistance.
  • Geographical mapping of cases.
  • Case-control analysis to identify risk factors.

Main Results:

  • 167 culture-proven enteric fever cases identified between April and July 2025.
  • 44 cases (26.35%) demonstrated ceftriaxone resistance.
  • A high proportion of resistant cases (81.82%) were concentrated in the GB Road area of Thane.
  • Tanker water supply was significantly associated with ceftriaxone resistance.

Conclusions:

  • The study identified a concerning outbreak of ceftriaxone-resistant enteric fever in Thane.
  • Contaminated tanker water is a significant risk factor for ceftriaxone-resistant enteric fever.
  • Public health interventions targeting water safety and antimicrobial stewardship are crucial.