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Ceftriaxone-Resistant Enteric Fever Outbreak in Children From Thane: A Multicenter Prospective Study
Sudhir Sane1, Sunil Junagade2, Mahesh Mohite3
1Department of Pediatrics, Jupiter Lifeline Hospitals, Off Eastern Express Highway, Thane West, Thane, Maharashtra, 400602, India. sudhirs4@hotmail.com.
Indian Pediatrics
|June 18, 2026
Summary
A study in India found ceftriaxone-resistant enteric fever, with tanker water linked to resistance. This highlights a critical public health issue in Thane, Maharashtra.
Area of Science:
- Infectious Disease Epidemiology
- Antimicrobial Resistance Surveillance
Background:
- Enteric fever outbreaks pose a significant public health challenge, particularly in resource-limited settings.
- Emerging antimicrobial resistance, including resistance to critical antibiotics like ceftriaxone, complicates treatment and increases morbidity.
Purpose of the Study:
- To investigate an outbreak of enteric fever in Thane, Maharashtra, India.
- To determine the prevalence of ceftriaxone resistance among enteric fever cases.
- To identify potential risk factors associated with ceftriaxone resistance.
Main Methods:
- Prospective study design.
- Culture-proven diagnosis of enteric fever.
- Antimicrobial susceptibility testing, focusing on ceftriaxone resistance.
- Geographical mapping of cases.
- Case-control analysis to identify risk factors.
Main Results:
- 167 culture-proven enteric fever cases identified between April and July 2025.
- 44 cases (26.35%) demonstrated ceftriaxone resistance.
- A high proportion of resistant cases (81.82%) were concentrated in the GB Road area of Thane.
- Tanker water supply was significantly associated with ceftriaxone resistance.
Conclusions:
- The study identified a concerning outbreak of ceftriaxone-resistant enteric fever in Thane.
- Contaminated tanker water is a significant risk factor for ceftriaxone-resistant enteric fever.
- Public health interventions targeting water safety and antimicrobial stewardship are crucial.
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