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Integrated Bioinformatics Methods Were Employed to Investigate Potential Molecular Links Between Obstructive Sleep
Yi Li1, Chengdian Lan1, Haiyan Lei1
1Department of General Practice, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China, fudan.edu.cn.
Mediators of Inflammation
|June 18, 2026
Summary
Obstructive sleep apnea (OSA) causally links to sarcoidosis, involving immune and inflammatory pathways. This research identifies key genes and develops predictive models for comorbid conditions.
Area of Science:
- Genomics
- Bioinformatics
- Pulmonology
Background:
- Obstructive sleep apnea (OSA) and sarcoidosis frequently co-occur.
- The molecular mechanisms linking OSA and sarcoidosis remain unclear.
Purpose of the Study:
- To investigate the causal relationship between OSA and sarcoidosis.
- To identify shared molecular mechanisms and potential biomarkers for comorbid OSA and sarcoidosis.
Main Methods:
- Utilized Mendelian randomization (MR) to assess causality.
- Performed colocalization, differential gene expression, and WGCNA analyses.
- Employed machine learning to construct predictive nomograms for comorbid risk.
Main Results:
- Confirmed a causal link between OSA and sarcoidosis (p=0.0018).
- Identified 35 shared genes, with 6 differentially expressed, including KRT72, DEFA4, RNASE3, and LTF as signature genes.
- Developed nomograms for predicting comorbid risk.
Conclusions:
- Established a causal relationship between OSA and sarcoidosis.
- Highlighted potential mechanisms involving immune dysregulation, inflammation, DNA repair, and apoptosis.
- Suggests further investigation into autophagy and neural activity in comorbidity.
