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Related Experiment Video

Updated: Jun 20, 2026

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

Microenvironment-Adaptive Dynamic Hydrogel with Hierarchical Therapeutic Functions for Infected Chronic Wound

Jie Xu1, Shuai Ye2, Yichen Liu3

  • 1Plastic and Cosmetic Center of Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 321000, China.

ACS Applied Materials & Interfaces
|June 18, 2026
PubMed
Summary

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A novel dynamic hydrogel (BBR/CAT@Gel) effectively treats infected chronic wounds by adapting to the wound microenvironment. It offers antibacterial, antioxidant, and regenerative properties, promoting complete healing in a mouse model.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Infected chronic wounds present a complex challenge due to persistent bacterial infection, oxidative stress, and inflammation.
  • Conventional dressings are often inadequate in addressing the multifactorial nature of these wounds.
  • A dynamic, adaptive therapeutic strategy is needed to break the cycle of chronic wound pathology.

Purpose of the Study:

  • To engineer a microenvironment-adaptive dynamic hydrogel (BBR/CAT@Gel) with hierarchical therapeutic functions for infected chronic wound management.
  • To investigate the hydrogel's ability to break the cascade of infection, oxidative stress, and inflammation.
  • To evaluate the hydrogel's efficacy in promoting wound regeneration and tissue repair.

Main Methods:

Keywords:
ROS scavenginganti-inflammationantibacterialdynamic hydrogelinfected chronic wound healingresponsive release

Related Experiment Videos

Last Updated: Jun 20, 2026

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

  • Fabrication of a dynamic hydrogel using dual dynamic covalent cross-linking (Schiff base and phenylboronate ester bonds).
  • Incorporation of berberine (BBR) and catalase (CAT) for antibacterial and antioxidant properties.
  • Evaluation of hydrogel's injectability, self-healing, tissue adhesion, and on-demand drug release in response to wound conditions (acidic pH, ROS).

    • Main Results:

    • The BBR/CAT@Gel demonstrated hierarchical therapeutic functions: contact killing, responsive drug release, and microenvironment remodeling.
    • Multifaceted antibacterial effects were achieved through membrane disruption and protein synthesis inhibition.
    • Released CAT and BBR scavenged reactive oxygen species (ROS), while chlorogenic acid (CGA) exhibited antioxidant activity, reduced M1 macrophage polarization, and promoted angiogenesis.
    • Complete epidermal regeneration with organized collagen deposition was observed in a mouse model of infected chronic wounds.

    Conclusions:

    • The rationally designed BBR/CAT@Gel hydrogel platform integrates hierarchical therapeutic mechanisms for advanced chronic wound management.
    • This microenvironment-adaptive hydrogel offers a compelling strategy to break the vicious cycle of infected chronic wounds.
    • The study highlights the potential of dynamic hydrogels in accelerating wound healing and tissue regeneration.