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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
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The Bronchial Tree

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Endoscopic Studies I: Bronchoscopy and Thoracoscopy01:30

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
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Respiratory System Abnormal Finding II: Palpation and Auscultation

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Physical Assessment of the Respiratory Tract IV: Auscultation01:28

Physical Assessment of the Respiratory Tract IV: Auscultation

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Breath Sounds
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Related Experiment Videos

[Errors and difficulties in diagnosing bronchiolar adenoma].

I V Dvorakovskaya1, G A Raskin2, S N Bugrov1

  • 1St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russia.

Arkhiv Patologii
|June 18, 2026
PubMed
Summary
This summary is machine-generated.

This case study details a rare ciliated muconodular papillary tumor, also known as bronchiolar adenoma, in a 65-year-old female. It emphasizes diagnostic challenges and presents histological, immunohistochemical, and molecular findings.

Keywords:
adenocarcinomabronchiolar adenomaciliated epitheliumcolumnar epitheliumlungsmucous cellsproximal and distal types

Related Experiment Videos

Area of Science:

  • Pulmonology
  • Surgical Pathology
  • Oncology

Background:

  • Ciliated muconodular papillary tumor (CMPTs), or bronchiolar adenomas, are rare lung neoplasms.
  • Distinguishing CMPTs from adenocarcinoma poses diagnostic challenges, particularly preoperatively and intraoperatively.
  • Bilateral lung lesions requiring surgical intervention for CMPT are exceptionally uncommon.

Purpose of the Study:

  • To present a rare clinical case of bilateral CMPT/bronchiolar adenoma.
  • To discuss the diagnostic difficulties in differentiating CMPTs from adenocarcinoma.
  • To illustrate the utility of multislice computed tomography, histology, immunohistochemistry, and molecular genetics in diagnosing CMPTs.

Main Methods:

  • Surgical resection of bilateral lung lesions.
  • Histopathological examination of resected tissue.
  • Immunohistochemical staining for diagnostic markers.
  • Multislice computed tomography (MSCT) imaging.
  • Molecular genetic analysis.

Main Results:

  • The patient was diagnosed with a ciliated muconodular papillary tumor/bronchiolar adenoma.
  • Differential diagnosis challenges with adenocarcinoma were highlighted during pre- and intraoperative assessments.
  • Histological and immunohistochemical features of both proximal and distal bronchiolar adenoma types were detailed.
  • Molecular genetic findings for bronchiolar adenoma were presented and compared with existing literature.

Conclusions:

  • Accurate diagnosis of bronchiolar adenoma requires a combination of advanced imaging, detailed histopathology, specific immunohistochemistry, and molecular analysis.
  • CMPTs present unique diagnostic challenges that necessitate careful evaluation to differentiate them from malignant lung neoplasms like adenocarcinoma.
  • This case underscores the importance of comprehensive diagnostic approaches for rare lung tumors.