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Updated: Jun 20, 2026

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)
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Published on: February 5, 2022

Structural basis for lysophosphatidic acid recognition and atypical Gαq coupling by LPAR5

Xin Li1,2, Kai Wang1,2, Zhongliang Xing3

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Proceedings of the National Academy of Sciences of the United States of America
|June 18, 2026
PubMed
Summary

Structural insights into Lysophosphatidic acid receptor 5 (LPAR5) reveal a unique G protein coupling mechanism. This discovery advances understanding of G protein-coupled receptor (GPCR) signaling and specificity in LPA receptors.

Keywords:
G protein-coupled receptorLPALPAR5ligand recognitionnon-canonical G protein coupling

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