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Expressed nocturnal high loop gain during sleep is associated with lower incident chronic airway disease and lung
Yue-Nan Ni1, Eline Oppersma2, Wolfgang Ganglberger3
1Department of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University, 610041, China; Department of Respiratory Care, West China School of Medicine and West China Hospital, Sichuan University, 610041, China.
Rationale:
High loop gain (HLG) of the respiratory control system during sleep, by enhancing respiratory drive, may reflect a more responsive ventilatory control mechanism and thereby be related to a lower rate of chronic airway disease progression.
Objective:
To determine the effect of computationally determined expressed high loop gain via respiratory self-similarity (SS%) during sleep and the related central respiratory event index (CREI), on new onset of chronic airway disease and lung disease related mortality.
Methods:
A secondary analysis of the Sleep Heart Health Study (SHHS) and the Osteoporotic Fractures in Men Study (MrOS). Both SS% and CREI were calculated from the chest and abdominal RIP signal. Logistic regression was applied to assess risk factors for incident chronic airway disease in the SHHS. Cox regression was done to explore the relationship between SS%, CREI and lung disease related mortality in the MrOS study.
Results:
A SS% >3.80% (OR: 0.566, 95% CI 0.373-0.857, p: 0.007) and CREI >10.20 events/h (OR: 0.604, 95% CI 0.389-0.937, p: 0.025) was related with a lower incidence of chronic airway disease in the SHHS. Individuals with SS% (Q3: HR: 0.539, 95% CI 0.327-0.888, p: 0.015; Q4: HR: 0.480, 95% CI 0.293-0.786, p: 0.004) and CREI (Q3: HR: 0.471, 95% CI 0.286-0.776, p:0.003; Q4: HR: 0.398, 95% CI 0.232-0.682, p:0.001) in the highest two quartiles had lower lung disease related mortality, respectively.
Conclusion:
Expressed high loop gain during sleep was associated with a lower incidence of chronic airway disease and lung disease related mortality.
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