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Published on: November 29, 2024
Triglyceride-Glucose-Waist-to-Height Ratio Index and Left Ventricular Diastolic Function in Military Athletes
Yen-Chen Lin1, Wei-Chieh Huang2, Sung-Hao Huang3
1Division of Cardiology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Background:
The triglyceride-glucose-waist-to-height ratio (TyG-WHtR) predicts heart failure, but its association with left ventricular diastolic function (LVDF) in physically fit individuals is unclear.
Objectives:
This study aimed to assess whether TyG-WHtR independently associates with echocardiographic LVDF indicators and exercise performance in physically active military personnel.
Methods:
In this cross-sectional analysis, 151 male and 25 female military personnel aged 18 to 44 years underwent biochemistry, echocardiography, and fitness testing (3-km run, push-ups, and sit-ups). Men were dichotomized at the median TyG-WHtR (3.954). Kendall correlations with bootstrap 95% CIs and Benjamini-Hochberg false discovery rate adjustment, plus theory-driven multivariable regression adjusted for age, sex, heart rate, atherogenic lipids, and TyG-WHtR, were used; multiplicative sex interaction was tested.
Results:
Higher- vs lower-TyG-WHtR men (4.41 [4.13, 4.74] vs 3.62 [3.38, 3.82]) were older (29 [23, 36] vs 25 [21, 30] years), with adverse cardiometabolic profile, lower mitral e' velocity and E/A, and worse exercise performance. TyG-WHtR was age-independently correlated with e' velocity (τ -0.382; 95% CI: -0.462 to -0.297) and E/A (-0.265; -0.367 to -0.165), both Benjamini-Hochberg-adjusted P < 0.001. In regression, TyG-WHtR was the leading e' predictor (standardized β -0.367; -0.491 to -0.242). Sex × TyG-WHtR interaction on e' velocity was statistically detectable (P = 0.012) but underpowered.
Conclusions:
TyG-WHtR is age-independently associated with subclinical LVDF decline and lower exercise capacity in young, physically active military personnel. Whether insulin resistance reduction could improve diastolic function requires further study.
