Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Hepatic Portal System01:21

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pancreas Cancer Risk During Intraductal Papillary Mucinous Neoplasm Surveillance - A SEER-Based Comparison.

Annals of surgery·2026
Same author

ASO Visual Abstract: The Margin of the Largest Tumor Predicts Overall Survival After Resection of Multi-tumor Colorectal Liver Metastases.

Annals of surgical oncology·2026
Same author

ASO Visual Abstract: Eligibility for Liver Transplantation in Patients with Intrahepatic Cholangiocarcinoma.

Annals of surgical oncology·2026
Same author

ASO Author Reflections: Redefining Surgical Margins in Multi-tumor Colorectal Liver Metastases.

Annals of surgical oncology·2026
Same author

Eligibility for Liver Transplantation in Patients with Intrahepatic Cholangiocarcinoma.

Annals of surgical oncology·2026
Same author

The Margin of the Largest Tumor Predicts Overall Survival After Resection of Multitumor Colorectal Liver Metastases.

Annals of surgical oncology·2026
Same journal

Completion Cholecystectomy: Indications and Outcomes After Subtotal Cholecystectomy.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same journal

Gastric Adenocarcinoma in the Excluded Stomach after Roux-en-Y Gastric Bypass: A Case Series, Systematic Review, and Diagnostic Algorithm.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same journal

Invited Commentary on: Comparative Effectiveness of Preoperative Prehabilitation Modalities for Postoperative Recovery in Colorectal Cancer: A Systematic Review and Network Meta-analysis.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same journal

Isolated Rectal Heterotopic Gastric Mucosa with Hemorrhage.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same journal

Minimizing chronic groin pain after inguinal hernia surgery: An augmented evidence review.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same journal

Beyond Incontinence: A Systematic Review and Meta-Analysis of Sexual Dysfunction after Anal Fistula Surgery.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
See all related articles

Related Experiment Video

Updated: Jun 20, 2026

Laparoscopic Anatomical Resection of the Right Anterior Lobe Based on the Laennec Capsule Technique
06:11

Laparoscopic Anatomical Resection of the Right Anterior Lobe Based on the Laennec Capsule Technique

Published on: May 2, 2025

Hepatic arterial infusion chemotherapy review.

Xavier L Baldwin1, Michael I D'Angelica1

  • 1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
|June 18, 2026
PubMed
Summary
This summary is machine-generated.

Hepatic artery infusion chemotherapy (HAIC) offers targeted liver cancer treatment. This review explores HAIC

Keywords:
Colorectal liver metastasisHepatic artery infusion chemotherapyHepatic neoplasmsIntrahepatic cholangiocarcinomaLiver-directed therapy

More Related Videos

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
05:31

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

Related Experiment Videos

Last Updated: Jun 20, 2026

Laparoscopic Anatomical Resection of the Right Anterior Lobe Based on the Laennec Capsule Technique
06:11

Laparoscopic Anatomical Resection of the Right Anterior Lobe Based on the Laennec Capsule Technique

Published on: May 2, 2025

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
05:31

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

Area of Science:

  • Oncology
  • Hepatobiliary Surgery
  • Cancer Therapeutics

Background:

  • Hepatic artery infusion chemotherapy (HAIC) is a liver-directed therapy.
  • The hepatic artery's blood supply to liver tumors underpins HAIC's efficacy.
  • Initially for unresectable colorectal liver metastasis (CRLM), HAIC's applications are expanding.

Purpose of the Study:

  • To review the historical development of HAIC.
  • To outline the evolution of HAIC treatment protocols.
  • To discuss current applications and outcomes of HAIC in liver cancer.

Main Methods:

  • Literature review of HAIC history and applications.
  • Analysis of treatment evolution and patient outcomes.
  • Synthesis of data on HAIC for CRLM and intrahepatic cholangiocarcinoma (ICC).

Main Results:

  • HAIC has evolved from a palliative to a therapeutic option.
  • Increasing adoption of HAIC programs globally.
  • Emerging roles in resectable CRLM and unresectable ICC.

Conclusions:

  • HAIC is a significant advancement in liver cancer therapy.
  • The prevalence and application of HAIC continue to grow.
  • Further research into HAIC outcomes is warranted.