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Hepatic arterial infusion chemotherapy review
Xavier L Baldwin1, Michael I D'Angelica1
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States.
Summary
Hepatic artery infusion chemotherapy (HAIC) offers targeted liver cancer treatment. This review explores HAIC
Area of Science:
- Oncology
- Hepatobiliary Surgery
- Cancer Therapeutics
Background:
- Hepatic artery infusion chemotherapy (HAIC) is a liver-directed therapy.
- The hepatic artery's blood supply to liver tumors underpins HAIC's efficacy.
- Initially for unresectable colorectal liver metastasis (CRLM), HAIC's applications are expanding.
Purpose of the Study:
- To review the historical development of HAIC.
- To outline the evolution of HAIC treatment protocols.
- To discuss current applications and outcomes of HAIC in liver cancer.
Main Methods:
- Literature review of HAIC history and applications.
- Analysis of treatment evolution and patient outcomes.
- Synthesis of data on HAIC for CRLM and intrahepatic cholangiocarcinoma (ICC).
Main Results:
- HAIC has evolved from a palliative to a therapeutic option.
- Increasing adoption of HAIC programs globally.
- Emerging roles in resectable CRLM and unresectable ICC.
Conclusions:
- HAIC is a significant advancement in liver cancer therapy.
- The prevalence and application of HAIC continue to grow.
- Further research into HAIC outcomes is warranted.
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