How many protein pairs can we chemically target?
Maria J Falaguera1, Tudor I Oprea2, Jordi Mestres3
1European Molecular Laboratory - European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, United Kingdom; Open Targets, Wellcome Genome Campus, Hinxton CB10 1SD, United Kingdom.
Abstract:
In the past 25 years, drugs acting on multiple targets by design have accounted for around one-fifth of annual new approvals. Beyond primary targets, drugs also interact, usually unintentionally, with multiple secondary targets. Here, we present a list of 64,222 target pairs currently being chemically targeted, representing 5% of all co-expressed dual combinations of proteins with a known interacting drug or bioactive ligand. In addition, we identified 7,253 target pairs that are likely to be chemically targetable, involving one protein with neither a drug nor a bioactive ligand known at present, but co-expressed and phylogenetically related to a chemically targeted protein. This catalogue of protein pairs offers a wealth of opportunities for the systematic design of future dual-action drugs.
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