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Transcatheter Aortic Valve Replacement Outcomes in Patients With Chronic Inflammatory Systemic Diseases
Beni Rai Verma1, Anita Sadeghpour2, Farah Bani Hani1
1MedStar Washington Hospital Center, Georgetown University, Washington, District of Columbia.
The American Journal of Cardiology
|June 18, 2026
Summary
Transcatheter aortic valve replacement (TAVR) is safe for patients with chronic inflammatory diseases (CIDs), showing similar outcomes to those without CIDs. However, CID patients experienced more vascular complications and interventions post-TAVR.
Area of Science:
- Cardiology
- Rheumatology
- Interventional Cardiology
Background:
- Transcatheter aortic valve replacement (TAVR) is a key treatment for aortic stenosis.
- The impact of chronic inflammatory diseases (CIDs) on TAVR outcomes is not well-established.
- Understanding these outcomes is crucial for patient selection and management.
Purpose of the Study:
- To evaluate the clinical impact of TAVR in patients with coexisting chronic inflammatory diseases (CIDs).
- To compare inpatient and one-year outcomes between TAVR patients with and without CIDs.
- To identify potential risks and benefits specific to TAVR in the CID population.
Main Methods:
- Retrospective study of 2,880 TAVR patients from 11/21/2011 to 03/29/2024.
- Patients were categorized into CID (n=185) and no-CID groups based on ICD codes.
- Clinical outcomes including in-hospital and one-year mortality, and complications were compared.
Main Results:
- The CID cohort had higher rates of female sex, immunosuppressive therapy, severe symptoms, and higher STS scores.
- In-hospital mortality was similar (0.0% vs 1.7%, p=0.08).
- Vascular complications (10.3% vs 6.1%, p=0.036) and unplanned vascular interventions (5.4% vs 1.9%, p=0.003) were significantly higher in the CID group.
- One-year mortality showed no significant difference (8.9% vs 8.91%, p=0.73).
Conclusions:
- TAVR is a safe procedure for patients with chronic inflammatory diseases.
- While overall mortality is comparable, TAVR patients with CIDs face increased risks of vascular access complications.
- Careful consideration of vascular access strategies and potential interventions is warranted for TAVR patients with CIDs.
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