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Diagnostic biomarkers for heart failure-related pleural effusion
Yi-Lu Hao1, Yan Niu2, Jian-Xun Wen2
1Center for Clinical Epidemiology Research, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China; Key Laboratory for Biomarkers, Inner Mongolia Medical University, Hohhot, China; Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Summary
Diagnosing heart failure (HF)-related pleural effusion is challenging. Natriuretic peptides and specific clinical scores like Porcel's and BANCA show high accuracy, offering objective diagnostic tools.
Area of Science:
- Cardiology
- Pulmonology
- Biomarker Research
Background:
- Pleural effusion is a common clinical condition with numerous causes, heart failure (HF) being a frequent one.
- Differentiating HF-related pleural effusion from other causes is difficult due to the subjectivity of current diagnostic methods like imaging and echocardiography.
- Objective, cost-effective, and minimally invasive diagnostic aids like biomarkers and scoring systems are needed.
Purpose of the Study:
- To review and summarize the diagnostic value of biomarkers and clinical scoring systems for identifying HF-related pleural effusion.
- To evaluate the research progress on specific biomarkers including natriuretic peptides, ischemia-modified albumin, and others, as well as scoring systems.
Main Methods:
- Systematic review of existing literature on biomarkers and scoring systems for HF-related pleural effusion.
- Analysis of diagnostic accuracy data for various biomarkers (e.g., natriuretic peptides, ischemia-modified albumin) and scoring systems (e.g., Porcel's score, BANCA score).
Main Results:
- Serum and pleural fluid natriuretic peptides (BNP, NT-proBNP, MR-proANP) demonstrated high and validated diagnostic accuracy for HF-related pleural effusion.
- Emerging biomarkers like ischemia-modified albumin require further validation.
- Porcel's score and BANCA score emerged as the most promising diagnostic scoring systems.
Conclusions:
- Natriuretic peptides are highly reliable biomarkers for diagnosing HF-related pleural effusion.
- Porcel's score and BANCA score are recommended as valuable tools for clinical diagnosis.
- Combining natriuretic peptides with validated scoring systems can improve diagnostic certainty.
Related Concept Videos
01:25Pleural Effusion I: Introduction
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's criteria,...
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's criteria,...
01:28Pleural Effusion II: Symptoms and Management
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
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01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:26Endoscopic Studies II: Thoracocentesis
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Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...
Description
Excess pleural fluid or air may accumulate in some respiratory disorders in the thoracic cavity. To treat pleural effusion, a physician conducts thoracentesis by carefully piercing the chest wall and entering...