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  1. Home
  3. Prevalence And Risk Factors Of Preserved Ratio Impaired Spirometry (prism) In People With Hiv And Matched Population Controls.
  1. Home
  3. Prevalence And Risk Factors Of Preserved Ratio Impaired Spirometry (prism) In People With Hiv And Matched Population Controls.

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Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
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Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

PREVALENCE AND RISK FACTORS OF PRESERVED RATIO IMPAIRED SPIROMETRY (PRISm) IN PEOPLE WITH HIV AND MATCHED POPULATION

Safura-Luise Heidari1, Josefine Amalie Loft1, Yunus Çolak2

  • 1Department of Infectious Diseases, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Chest
|June 18, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

People with HIV (PWH) have a significantly higher prevalence of preserved ratio impaired spirometry (PRISm) and restrictive spirometry patterns (RSP) compared to the general population. HIV infection is independently associated with these distinct lung function impairments.

Keywords:
HIVLung functionObstructive spirometryPreserved ratio impaired spirometryRestrictive spirometrySmoking

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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Published on: July 24, 2013

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • People with HIV (PWH) experience a greater burden of respiratory conditions than the general population.
  • Emerging spirometry impairments, including preserved ratio impaired spirometry (PRISm) and restrictive spirometry patterns (RSP), are understudied in PWH.
  • Understanding these specific lung function abnormalities is crucial for comprehensive care of PWH.

Purpose of the Study:

  • To investigate the association between HIV status and the prevalence of PRISm and RSP.
  • To determine if these spirometry impairments are more common in well-treated PWH in high-income settings compared to controls.
  • To explore the independent association of HIV with PRISm and RSP, adjusting for various risk factors.

Main Methods:

  • A cross-sectional study comparing 1,080 PWH with 12,079 matched population controls.
  • PRISm defined as FEV1/FVC ≥ LLN and FEV1 < LLN; RSP defined as FEV1/FVC ≥ LLN and FVC < LLN.
  • Multivariable logistic regression analyses were used, adjusting for demographic, lifestyle, and clinical factors.

    • Main Results:

    • Prevalence of both PRISm (10.5% vs. 3.5%) and RSP (10.6% vs. 3.2%) was significantly higher in PWH compared to controls.
    • These differences remained significant even in analyses restricted to never-smokers.
    • HIV was independently associated with PRISm (OR, 3.40) and RSP (OR, 4.34) after full adjustment for risk factors. PWH with these impairments reported more respiratory symptoms.

    Conclusions:

    • PWH exhibit substantially higher prevalences of PRISm and RSP compared to the general population.
    • HIV is independently associated with these specific lung function impairments, suggesting they are distinct manifestations of HIV-associated lung disease.
    • These findings highlight the need for increased awareness and screening for PRISm and RSP in PWH.