Nearest-neighbors assisted unsupervised analysis for methylation array profiling for central nervous system tumors
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Updated: Jun 20, 2026
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Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
Published on: July 12, 2012
Mallika Gandham1, Surendra Dasari1, Cherisse Marcou2
1Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Brain Pathology (Zurich, Switzerland)
|June 18, 2026
Abstract:
The NN method identifies the five nearest reference dataset neighbors to a tested sample and provides an objective estimation of the tested sample methylation class cluster rather than relying on subjective visualization using dimensionality reduction methods such as UMAP and t-SNE.
