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Related Concept Videos

Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

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Related Experiment Video

Updated: Jun 20, 2026

A Novel Technique for Raman Analysis of Highly Radioactive Samples Using Any Standard Micro-Raman Spectrometer
07:52

A Novel Technique for Raman Analysis of Highly Radioactive Samples Using Any Standard Micro-Raman Spectrometer

Published on: April 12, 2017

The Detection of Radiation Effects in the Urine of Rhesus Macaques Using Raman Spectroscopy.

Courtney S Moore, Amr Sayed Issa, Lacey Ngo

    Radiation Research
    |June 18, 2026
    PubMed
    Summary

    Raman spectroscopy in urine shows potential for detecting radiation effects and sarcomas in macaques. While a definitive radiation fingerprint wasn't found, distinct spectral profiles for sarcomas offer promising diagnostic avenues.

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    Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy
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    Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy

    Published on: May 18, 2011

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    Last Updated: Jun 20, 2026

    A Novel Technique for Raman Analysis of Highly Radioactive Samples Using Any Standard Micro-Raman Spectrometer
    07:52

    A Novel Technique for Raman Analysis of Highly Radioactive Samples Using Any Standard Micro-Raman Spectrometer

    Published on: April 12, 2017

    Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy
    15:04

    Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy

    Published on: May 18, 2011

    Area of Science:

    • Biomedical Engineering
    • Analytical Chemistry
    • Radiation Oncology

    Background:

    • Ionizing radiation exposure is linked to cancer development.
    • Current diagnostic methods lack specific biomarkers for early detection of radiation effects or neoplasms.
    • Developing biomarkers for monitoring radiotherapy efficacy and side effects is crucial.

    Purpose of the Study:

    • To investigate Raman Molecular Urinalysis for detecting radiation exposure and radiation-induced sarcomas in rhesus macaques.
    • To establish a potential urine-based biomarker for radiation treatment effects.

    Main Methods:

    • Retrospective analysis of 76 urine samples from irradiated and non-irradiated rhesus macaques.
    • Utilized Raman spectroscopy to analyze urine samples.
    • Applied principal component analysis and discriminant analysis to spectral data.

    Main Results:

    • Irradiated animals showed more variability in urine spectra compared to controls.
    • Animals with sarcomas exhibited a distinct spectral profile with high specificity.
    • A definitive radiation-specific spectral fingerprint was not identified.

    Conclusions:

    • Raman Molecular Urinalysis shows promise in identifying spectral differences associated with radiation exposure and sarcomas.
    • Further research is needed to clarify outlier spectral characteristics in irradiated animals.
    • Distinct sarcoma-associated spectral profiles suggest potential for future diagnostic applications.