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Developing a core outcome set for intervention studies in post stroke cognitive impairment (COS-PSCI): a protocol
Sinead Purcell1,2,3, Katie Robinson4,2,3,5, Margaret O'Connor3,6,7
1School of Allied Health, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland purcell.sinead@ul.ie.
BMJ Open
|June 18, 2026
Summary
This study will develop a standardized Core Outcome Set for Post-Stroke Cognitive Impairment (COS-PSCI) to improve research comparability and clinical translation for stroke survivors. The COS-PSCI will enhance outcome measurement consistency in intervention studies.
Area of Science:
- Neurology
- Clinical Research Methodology
- Rehabilitation Science
Background:
- Post-stroke cognitive impairment (PSCI) significantly affects stroke survivors' quality of life and independence.
- Current cognitive assessment and intervention research for PSCI lack standardized outcome measures, hindering comparability and clinical translation.
- A Core Outcome Set (COS) for PSCI is needed to standardize outcome measurement in intervention studies.
Purpose of the Study:
- To develop a Core Outcome Set for Post-Stroke Cognitive Impairment (COS-PSCI) specifically for intervention research.
- To establish consensus on essential outcomes and measurement instruments for PSCI research.
Main Methods:
- The study follows the COS-STAD framework, involving a scoping review, qualitative evidence synthesis, and focus groups.
- A modified eDelphi survey and international consensus meetings will prioritize outcomes and select measurement instruments (guided by COSMIN).
- Patient and public involvement is integrated throughout the six-stage development process.
Main Results:
- The study is in the development phase and has not yet produced results.
- The planned methodology will yield a consensus-driven COS-PSCI.
Conclusions:
- The development of a COS-PSCI is crucial for standardizing outcome measurement in post-stroke cognitive impairment research.
- This standardized approach will enhance the comparability of intervention studies and facilitate the translation of research findings into clinical practice.
