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Cost-effectiveness-oriented management (CEOM) of cardiovascular risks at primary healthcare settings in Anhui, China:

Xuanhe Liu1, Mengxue Liu1, Ying Zheng1

  • 1School of Health Service Management, Anhui Medical University, Hefei, China.

BMJ Open
|June 18, 2026
PubMed

Insights

This study introduces a cost-effectiveness-oriented management (CEOM) intervention for cardiovascular disease (CVD) in China. The CEOM approach aims to optimize CVD risk and harm management in primary care, improving patient outcomes and healthcare efficiency.

Area of Science:

  • Public Health
  • Health Economics
  • Primary Care Research

Background:

  • Cardiovascular disease (CVD) poses a significant health and economic burden in China.
  • Current CVD management in primary care lacks optimal cost-effectiveness.
  • This study addresses the need for improved CVD management strategies in Chinese primary healthcare settings.

Purpose of the Study:

  • To test the efficacy of an integrated, cost-effectiveness-oriented management (CEOM) intervention.
  • To improve CVD risk and harm management in primary healthcare settings in Anhui, China.
  • To evaluate the cost-effectiveness of the CEOM intervention using Quality-Adjusted Life Years (QALYs).

Main Methods:

  • An open-label, multi-centre, cluster-randomised controlled trial in 32 village clinics in Anhui, China.
  • Randomisation of clinics to either the CEOM intervention or usual care (1:1 ratio).
  • Integration of prospective cost-effectiveness analysis into clinical workflow, guiding tailored patient management based on predicted incremental cost-effectiveness ratios (ICERs).

Main Results:

  • The primary outcome is the incremental cost-effectiveness ratio (ICER) evaluated using Quality-Adjusted Life Years (QALYs) at 12 and 24 months.
  • Secondary outcomes include changes in patient knowledge, attitudes, and practices, major adverse cardiovascular events, and overall costs.
  • Data analysis will employ linear mixed models and generalised estimating equations following the intention-to-treat principle.

Conclusions:

  • The CEOM intervention is expected to enhance CVD risk and harm management in Chinese primary care.
  • This approach aims to improve patient outcomes while optimizing healthcare resource allocation.
  • Findings will inform policy and practice for more cost-effective CVD management in similar settings.
Abstract

Keywords:
Cardiovascular DiseaseHealth economicsPrimary Health CareRandomized Controlled Trial

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