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Related Experiment Video

Updated: Jun 20, 2026

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Unilateral striatal deep brain stimulation improves cognitive control.

Elizabeth M Sachse1,2, Evan M Dastin-van Rijn1,3, Jon P Bennek1,3

  • 1Department of Psychiatry & Behavioral Sciences, University of Minnesota, 606 24th Ave S, Minneapolis, MN 55454.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|June 18, 2026
PubMed
Summary

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This summary is machine-generated.

Unilateral deep brain stimulation (DBS) effectively improves cognitive control, matching bilateral stimulation benefits. This research validates a rodent model for studying DBS mechanisms in psychiatric disorders, noting equal efficacy in females.

Area of Science:

  • Neuroscience
  • Psychiatric Disorders
  • Medical Devices

Background:

  • Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VCVS) treats psychiatric conditions like OCD by enhancing cognitive control.
  • Optimizing DBS efficacy is challenging due to incomplete understanding of stimulation parameters and target effects.
  • Human studies suggest right-unilateral VCVS DBS is most effective, but preclinical models haven't fully explored laterality.

Purpose of the Study:

  • To investigate laterality effects in a rodent model of VCVS DBS for cognitive control.
  • To compare the effects of bilateral, left-unilateral, and right-unilateral mid-striatal stimulation on cognitive control.
  • To determine if sex influences cognitive control improvement from stimulation.

Main Methods:

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  • Developed a rodent model of VCVS DBS focusing on cognitive control.
  • Administered bilateral, left-unilateral, and right-unilateral mid-striatal stimulation.
  • Utilized computational modeling to analyze the effects of stimulation on decision-making variables.

    • Main Results:

    • Both right and left-unilateral stimulation improved cognitive control by reducing response times without affecting accuracy.
    • Computational modeling indicated that unilateral and bilateral stimulation modify the same decision-making variables.
    • Females showed equivalent cognitive control improvement from stimulation compared to males.

    Conclusions:

    • Unilateral mid-striatal stimulation can be as effective as bilateral stimulation in enhancing cognitive control.
    • The rodent model is a valid translational platform for studying VCVS DBS mechanisms, including laterality and sex effects.
    • Findings support the potential for unilateral DBS to maximize therapeutic benefits while minimizing invasiveness and off-target effects.