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Updated: Jun 20, 2026

Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis
Published on: February 3, 2022
Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints
José L Cabrera-Alarcón1, José A Enríquez1
1Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain; CIBER de Fragilidad Y Envejecimiento Saludable (CIBERFES), Madrid, Spain.
None:
Recent advances integrating high-resolution 3D structures with population genetics and comparative evolutionary analyses indicate that mitochondrial DNA (mtDNA) acts as a primary evolutionary engine driving nuclear coadaptation. This process reflects a trade-off between individual heterozygosity and mtDNA-driven variability, which together expand the mitonuclear haplotype pool within species.
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