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Updated: Jun 20, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
Nanotechnology-mediated precision delivery of mRNA
Hongzhang Deng1,2,3, Lin Li4,5,6, Caiyan Zhao4,5,6
1School of Life Science and Technology, Xidian University and Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi'an, China. hzdeng@xidian.edu.cn.
None:
Messenger RNA-based therapeutics have been successful in preventing and treating various diseases. Nonetheless, these therapies still face difficulties in achieving specific delivery to organs, tissues and cells, which are exacerbated by the need to overcome multilevel biological barriers and intrinsically complex physiological disease characteristics. Several approaches are being developed to overcome these challenges, including optimizing administration routes, enhancing targeting abilities and facilitating responsive release. These tailored design strategies have been utilized in applications including mRNA vaccines, protein replacement and gene editing for enhanced precision therapies. This Review discusses various heterogeneous barriers for mRNA delivery and nanocarrier-mediated mRNA precision-delivery strategies, and highlights their uses in biomedical applications. Moreover, we discuss current limitations and future perspectives to accelerate the development of precision mRNA delivery to address current clinical needs.
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