Related Experiment Video
Updated: Jun 20, 2026
The Pocket-Creation Procedure of Endoscopic Submucosal Dissection for Large Rectal Laterally Spreading Tumors
Published on: February 13, 2026
Recurrence rates following endoscopic mucosal resection versus endoscopic submucosal dissection for colorectal
Tomoyuki Nishimura1, Kareem Khalaf1, Mohamed Abdulla Ghuloom Abdulla Bucheeri1
1Division of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Background And Aims:
Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are widely used for resecting large, laterally spreading colorectal polyps. While ESD offers higher en bloc resection rates, its comparative efficacy and safety relative to EMR remain uncertain, particularly in Western practice. This systematic review and meta-analysis aimed to evaluate the recurrence and adverse event rates of EMR versus ESD in adult patients with colorectal polyps ≥ 20 mm.
Methods:
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing EMR and ESD for colorectal polyps. Ovid MEDLINE and Embase were searched from inception to April 2024. The primary outcome was recurrence rate; secondary outcomes included total adverse events, bleeding, and perforation. Certainty of evidence was assessed using the GRADE framework.
Results:
In this meta-analysis of three randomized controlled trials including 484 patients, ESD was associated with significantly lower recurrence rates compared to EMR (OR 3.24, 95% CI: 1.58-6.64), with high certainty of evidence. There were no significant differences between EMR and ESD in total adverse events (OR 0.96, 95% CI: 0.43-2.17), bleeding (OR 0.96, 95% CI: 0.41-2.27), or perforation rates (OR 0.96, 95% CI: 0.14-6.65), though certainty for these outcomes was moderate due to heterogeneity and imprecision.
Conclusion:
ESD is associated with significantly lower recurrence rates compared to EMR in the treatment of large colorectal polyps, with high-certainty evidence. These findings support the use of ESD when recurrence risk is a primary concern, while EMR remains a feasible alternative with comparable safety.
Prospero:
CRD420251048732.
