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Related Experiment Video

Updated: Jun 20, 2026

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

The hippocampus becomes topographically and functionally specialized along the longitudinal axis with development.

Jonah Kember¹, Ying He², Zeus Gracia-Tabuenca^2,3

¹McGill University, Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada. jonah.kember@mail.mcgill.ca.

Nature Communications

|June 18, 2026

Summary

The developing human hippocampus shows significant changes along its long-axis, with the posterior system becoming more specialized. This specialization may explain improvements in visuospatial memory during childhood and adolescence.

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Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

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Last Updated: Jun 20, 2026

Horizontal Hippocampal Slices of the Mouse Brain

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

Area of Science:

Neuroscience
Developmental Neuroscience
Cognitive Neuroscience

Background:

The human hippocampus has distinct anterior-posterior profiles affecting visuospatial processing.
Developmental changes in the hippocampus may underlie enhanced memory capacity.

Purpose of the Study:

To investigate developmental remodeling of the hippocampal long-axis.
To correlate these changes with visuospatial memory development.

Main Methods:

Developed a precision functional mapping technique using BOLD-fMRI.
Analyzed data from 471 participants aged 5-21.
Examined changes in surface area and BOLD activity patterns.

Main Results:

Observed significant developmental remodeling of the hippocampal long-axis.
Posterior system surface area decreased by 39.4% with age.
Posterior system activity became more independent with sharper boundaries.
Connectivity with medial-parietal regions increased and correlated with age and memory scores.

Conclusions:

The hippocampal long-axis undergoes topographic and functional specialization during development.
This specialization likely contributes to increased visuospatial memory capacity with age.