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Updated: Jun 20, 2026
Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
Published on: June 20, 2025
The relationship between inflammatory markers and the severity and prognosis of neurological dysfunction in stroke
Xile Zhang1, Luyu Li2, Qing Lin1
1Department of Neurology, Wenzhou Medical University Huangyan Hospital, Taizhou First People's Hospital, Zhejiang, Taizhou, 318020, People's Republic Of China.
Background:
The aim of this study is to explore the relationship of inflammatory indicators with the severity and prognosis of neurological dysfunction in stroke patients, and to evaluate the prognostic value of inflammatory indicators for patients suffering from acute ischemic stroke (AIS).
Methods:
The study recruited 225 AIS patients and 46 healthy individuals, and collected their clinical data and hematological indicators. Calculate six inflammatory markers and evaluate the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) scores at admission, discharge, 1 months of onset and 3 months of onset. Correlation analysis, multivariate logistic regression analyses, the receiver operating characteristic (ROC) curve and the area under the curve (AUC) were used to analyze the relationship of inflammatory markers with the severity and prognosis of stroke.
Results:
Elevated levels of neutrophil to lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and pan immune-inflammation value (PIV) were observed in patients at admission (p < 0.05). Most inflammatory markers are positively correlated with the severity of neurological deficits during the acute phase, especially upon admission and discharge. Higher admission lymphocyte to monocyte ratio (LMR) levels are independently associated with larger infarct volume and adverse functional outcomes. In contrast, indicators like NLR, SIRI and PIV showed associations in the opposite direction (odds ratios < 1), suggesting complex interactions that require further investigation. For different time points, NLR showed the greatest prognostic value at admission (AUC = 0.654) and PIV at discharge (AUC = 0.725).
Conclusions:
These inflammatory markers exhibit characteristic dynamic changes after AIS and have close relationship with the severity and prognosis of neurological deficits. It may contribute to early risk stratification and personalized treatment soon after.
