Related Experiment Video

Updated: Jun 20, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

Association between microinflammatory state and cardiac valvular calcification in patients undergoing maintenance

Meiyu Liu1, Peishan Peng1, Jie Chen2

  • 1Department of Nephrology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.

BMC Nephrology
|June 19, 2026
PubMed

Insights

The CALLY index, a novel marker, is linked to cardiac valvular calcification severity in maintenance hemodialysis patients. It offers improved prediction of multi-valvular involvement compared to other biomarkers.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarker Research

Background:

  • Microinflammation is prevalent in maintenance hemodialysis (MHD) patients.
  • Cardiac valvular calcification (CVC) is a common complication in MHD patients.
  • Predictive markers for CVC severity in MHD are needed.

Purpose of the Study:

  • To investigate the association between microinflammation and CVC in MHD patients.
  • To compare the C-reactive protein-albumin-lymphocyte (CALLY) index with other biomarkers for predicting CVC severity.

Main Methods:

  • A cross-sectional study of 203 MHD patients categorized by CVC severity.
  • Serum inflammatory markers (hs-CRP, IL-6, TNF-α) and routine biochemical parameters were measured.
  • Calculated CALLY index, NLR, CAR, PNI, GNRI; utilized logistic regression, ROC curves, NRI/IDI analyses.

Main Results:

  • CVC prevalence was 67.0% in the study population.
  • The CALLY index was independently associated with single and double valve calcification.
  • CALLY index showed superior predictive performance (C-statistic 0.869) and incremental value for multi-valvular involvement.

Conclusions:

  • The CALLY index is an independent predictor of CVC severity in MHD patients.
  • The CALLY index significantly enhances the prediction of multi-valvular calcification.
  • This index offers valuable insights for managing CVC in MHD patients.
Abstract

Keywords:
CALLY indexCardiac valvular calcificationInflammationMaintenance hemodialysis

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