Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of the Unfolded Protein Response by Viruses: Mechanistic Insights and Implications for viral Pathogenesis.

Current protein & peptide science·2026
Same author

Cold-Induced Gouty Arthritis: Exploring the Pathophysiological Link between Hyperuricemia and Gout Flare Triggers.

Current medicinal chemistry·2026
Same author

Herbal remedies for hepatic diseases: A review of medicinal herbs in the treatment of liver disorders.

Chinese herbal medicines·2026
Same author

Retrospection of Argemone mexicana and its Derived Analogs as a Futuristic Approach Exhibiting Anticancer Potential.

Mini reviews in medicinal chemistry·2026
Same author

Molecular Landscape of Natural Compounds and Tailored Signaling Pathways in the Battle Against Breast Cancer.

Current pharmaceutical design·2026
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026

Related Experiment Video

Updated: Jun 20, 2026

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

Targeting the Tumor Extracellular Matrix: A New Frontier in Cancer Therapy.

Anjana Goel1, Istuti Saraswat1, Swadha Pandey1

  • 1Department of Biotechnology, GLA University, 17km Stone, NH_19 Mathura-Delhi Road, Mathura, Chaumuhan, Mathura, Uttar Pradesh, India.

Current Cancer Drug Targets
|June 19, 2026
PubMed
Summary

Targeting the extracellular matrix (ECM) in cancer offers new therapeutic strategies. Modifying the tumor microenvironment (TME) can enhance drug efficacy and restore anti-cancer immune responses.

Keywords:
Cell-ECM interactionsECM-targeted therapeuticsTumor microenvironmentmatrix remodelling enzymesmetastatic signaling pathwaysoncogenic ECM dynamics.

More Related Videos

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract (ECME)-based Three-dimensional System
10:55

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract (ECME)-based Three-dimensional System

Published on: January 8, 2018

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy
09:00

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

Published on: April 22, 2014

Related Experiment Videos

Last Updated: Jun 20, 2026

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
05:48

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

Published on: March 18, 2014

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract (ECME)-based Three-dimensional System
10:55

Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract (ECME)-based Three-dimensional System

Published on: January 8, 2018

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy
09:00

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

Published on: April 22, 2014

Area of Science:

  • Oncology
  • Biochemistry
  • Cell Biology

Background:

  • The extracellular matrix (ECM) is vital for tissue structure and cell function.
  • In cancer, ECM remodeling promotes tumor growth, metastasis, and treatment resistance.
  • Altered ECM mechanics disrupt cell signaling via mechanotransduction.

Purpose of the Study:

  • To review novel cancer treatment strategies targeting the extracellular matrix (ECM).
  • To explore how ECM targeting can overcome treatment resistance and enhance immunotherapy.

Main Methods:

  • Enzymatic degradation of tumor-associated ECM.
  • Inhibition of lysyl oxidase (LOX/LOXL2) enzymes.
  • Matrix normalization and ECM-responsive drug delivery systems.
  • Reprogramming cancer-associated fibroblasts (CAFs).

Main Results:

  • Targeting ECM components and modifying enzymes shows promise in preclinical and clinical studies.
  • Selective ECM targeting can improve drug delivery and efficacy.
  • Restoration of anti-cancer immune responses is observed with ECM-modulating therapies.

Conclusions:

  • Targeting tumor-specific ECM abnormalities is a promising strategy for aggressive, stroma-rich cancers.
  • Combination therapies involving ECM modulation can enhance treatment outcomes.
  • Understanding ECM dynamics is crucial for developing effective cancer therapies.