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Causal Relationship Between 91 Inflammatory Factors and Gastritis: A Two-Sample Bidirectional Mendelian Randomization
1Department of Clinical Laboratory, The Fourth People's Hospital of Chengdu, Sichuan province, China.
Current Molecular Medicine
|June 19, 2026
Summary
This study used Mendelian Randomization to investigate inflammation
Area of Science:
- Gastroenterology
- Immunology
- Genetics
Background:
- Inflammation is implicated in gastrointestinal diseases.
- Causal links between inflammation and gastritis require validation.
Purpose of the Study:
- To evaluate the causal effects of inflammatory factors on gastritis using Mendelian Randomization.
- To identify potential biomarkers for acute and chronic gastritis.
Main Methods:
- Mendelian Randomization analysis utilizing GWAS and FinnGen databases.
- Assessment of 91 inflammatory factors for association with acute and chronic gastritis.
- Statistical tests for heterogeneity (Cochran's Q) and pleiotropy (MR-Egger's intercept).
Main Results:
- Identified specific inflammatory factors associated with acute gastritis (Axin-1, CXCL10, Fms-related tyrosine kinase 3 ligand).
- Linked distinct factors to chronic gastritis (CXCL10, GDNF, LIFR, HGF, FGF19).
- Reverse MR showed chronic gastritis downregulates specific inflammatory factors (e.g., LIFR, IL-2Rβ).
Conclusions:
- Acute and chronic gastritis involve distinct inflammatory profiles.
- Chronic gastritis can inversely affect inflammatory factor levels.
- CXCL10 and LIFR show potential as gastritis biomarkers.
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