A Case of Localized Gastric Amyloidosis With Improvement on Endoscopy After Eradication of Helicobacter pylori

Amyloidosis is a disease characterized by the abnormal accumulation of amyloids in tissues. The kidneys and heart are the most commonly affected organs in systemic amyloidosis. Primary localized gastric amyloidosis (LGA), on the other hand, is relatively rare. Some past studies have suggested a potential link between Helicobacter pylori infection and LGA, but more research is needed in order to support this hypothesis. A 37-year-old female patient complained of nausea and underwent an endoscopic examination. A 3.0-cm depressed mucosal lesion and mucosal fragility were observed in the upper and posterior gastric wall. She was referred to our hospital with ulcerative bleeding. The silver and Congo red staining results were positive. Echocardiography and abdominal computed tomography were performed to rule out systemic amyloid, and no evidence of systemic involvement was observed. Eradication therapy with standard triple therapy was administered, and successful eradication was confirmed. Two years after the successful eradication, an endoscopic follow-up examination revealed mucosal retraction; however, the mucosal inflammation, including edema and mucosal softening, significantly improved.