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Related Experiment Video

Updated: Jun 20, 2026

Isolation of Functional Cardiac Immune Cells
07:26

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Published on: December 5, 2011

Mast Cells and Cardiovascular Disorders.

Antonis A Manolis1, Theodora A Manolis2, Apostolos Vouliotis3

  • 1Department of Medicine, Elpis General Hospital, Athens, Greece.

Current Vascular Pharmacology
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

Mastocytosis and mast cell activation syndrome (MCAS) involve mast cell proliferation or activation, impacting cardiovascular health. Understanding these conditions is crucial for developing effective mast cell stabilizer therapies.

Keywords:
Mast cellsacute coronary syndrome.allergic anginaangioedemaatherosclerosiscardiovascular diseasemast cell degranulationmast cell stabilizersmastocytosisurticaria

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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Oncology

Background:

  • Mastocytosis involves clonal mast cell (MC) proliferation, while mast cell activation syndrome (MCAS) involves inappropriate MC activation without proliferation.
  • MCs are strategically located in cardiac tissues and atherosclerotic plaques, releasing mediators that influence inflammation, fibrosis, and cardiovascular diseases (CVD).
  • MCAS is increasingly recognized in patients with idiopathic chronic inflammatory, allergic diseases, or dystrophisms.

Purpose of the Study:

  • To review the role of mast cells and MCAS in cardiovascular diseases.
  • To highlight the mechanisms by which MC mediators contribute to atherosclerosis, plaque instability, and myocardial fibrosis.
  • To discuss the need for guidance on selecting mast cell stabilizers for clinical use.

Main Methods:

  • Literature review of mastocytosis, MCAS, and their cardiovascular implications.
  • Analysis of the role of MC mediators in cardiac inflammation, remodeling, and disease pathogenesis.
  • Discussion of diagnostic approaches and therapeutic strategies, including mast cell stabilizers.

Main Results:

  • MCs and their mediators play significant roles in atherosclerosis, plaque rupture, and post-myocardial infarction fibrosis.
  • MCAS contributes to various symptoms like flushing, hypotension, and gastrointestinal issues.
  • Diagnosis typically involves skin/bone marrow biopsy, with emerging therapeutic options.

Conclusions:

  • Mast cells and MCAS are implicated in a spectrum of cardiovascular conditions, necessitating clinical attention.
  • Further research and clinical guidance are needed for effective use of mast cell stabilizers.
  • Novel therapies targeting mast cell activation hold promise for managing MC-related cardiovascular diseases.