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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Migraine in children and adolescents

Ishaq Abu-Arafeh1

  • 1Paediatric Neurosciences Unit, Royal Hospital for Children, Glasgow, UK.

Developmental Medicine and Child Neurology
|June 19, 2026
PubMed

Insights

Migraine in children and adolescents involves complex genetics and varied symptoms, including related childhood migraine syndromes. Advances offer targeted treatments, but clinical assessment remains key due to a lack of biomarkers.

Area of Science:

  • Neurology
  • Pediatrics
  • Genetics

Background:

  • Migraine is a complex neurological disorder with a polygenic aetiology.
  • Its presentation is influenced by intrinsic and extrinsic factors.
  • Childhood migraine encompasses various related disorders.

Purpose of the Study:

  • To review recent advances in migraine research.
  • To focus on the aetiology, pathogenesis, and clinical presentation in children and adolescents.
  • To explore potential new mechanism-based treatments.

Main Methods:

  • Narrative review of current literature.
  • Emphasis on genetic and pathophysiological studies.
  • Analysis of clinical presentations and treatment strategies.

Main Results:

  • Migraine pathophysiology involves multiple neurotransmitters.
  • New targeted treatments for acute episodes and prevention are emerging.
  • Clinical assessment is crucial for diagnosis in the absence of biomarkers.

Conclusions:

  • Understanding migraine complexity reveals the need for personalized treatment approaches.
  • No single medication will suit all patients.
  • Further research into specific mechanisms is essential for effective management.

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