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Related Concept Videos

Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
Diabetic Ketoacidosis l: Introduction01:25

Diabetic Ketoacidosis l: Introduction

DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic ketone production, and...

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Related Experiment Video

Updated: Jun 20, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Changes in Inpatient Coding for Hepatic Encephalopathy After Introduction of ICD-10 Code K76.82.

Spencer R Goble1, Thomas M Leventhal1

  • 1Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Liver International : Official Journal of the International Association for the Study of the Liver
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

The new ICD-10 code K76.82 for hepatic encephalopathy (HE) significantly altered how HE is documented in hospital records. Its introduction led to a decrease in non-specific HE codes and increased use of the specific code.

Keywords:
hepatic encephalopathy (HE)hospitalizationinpatientsinternational classification of diseases

Related Experiment Videos

Last Updated: Jun 20, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

Area of Science:

  • Hepatology
  • Medical Informatics
  • Health Services Research

Background:

  • Hepatic encephalopathy (HE) is a serious complication of liver disease.
  • Accurate coding of HE is crucial for research and patient care.
  • Previous HE identification relied on non-specific ICD-10 codes.

Purpose of the Study:

  • To evaluate the impact of the new ICD-10 code K76.82 on HE documentation.
  • To assess changes in the utilization of HE-related ICD-10 codes after October 2022.

Main Methods:

  • Analysis of the National Inpatient Sample (NIS) database.
  • Comparison of ICD-10 code usage for HE before (2016-2021) and after (2023) the introduction of K76.82.
  • Assessment of HE documentation in cirrhosis hospitalizations.

Main Results:

  • Non-specific HE codes were present in 20.0% of cirrhosis hospitalizations from 2016-2021.
  • This decreased to 4.7% in 2023.
  • The specific HE code K76.82 was utilized in 20.3% of hospitalizations in 2023.

Conclusions:

  • The introduction of ICD-10 code K76.82 has substantially changed HE documentation practices.
  • Future research on HE trends and outcomes must consider this coding shift.
  • Improved specificity in HE coding is now possible.