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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jun 20, 2026

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

Grisotti versus Wise-Pattern Oncoplastic Reconstruction in Central Breast Cancer: A Randomized Controlled Study.

Ismail Ahmed Shafik1, Sherif Mohamed Mokhtar1, Kerolos A Barsoum1

  • 1Department of General Surgery, Cairo University Faculty of Medicine, Cairo, Egypt.

European Journal of Breast Health
|June 19, 2026
PubMed
Summary

The Grisotti flap and Wise-pattern reconstruction offer comparable oncological safety and aesthetic results for central breast tumors in breast-conserving surgery. Technique selection should be individualized based on patient anatomy and breast volume.

Keywords:
Grisotti flapOncoplastic breast surgeryWise-pattern oncoplastic reconstructionaesthetic outcomesbreast-conserving surgerycentral breast cancernipple-areola complex excisionsurgical margins

Related Experiment Videos

Last Updated: Jun 20, 2026

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
03:07

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

Published on: August 19, 2025

Area of Science:

  • Oncoplastic surgery
  • Breast reconstruction
  • Surgical oncology

Background:

  • Central breast tumors requiring nipple-areola complex excision pose a reconstructive challenge in breast-conserving surgery.
  • Volume-displacement oncoplastic techniques aim to preserve the breast while ensuring oncological safety.
  • The Grisotti flap and Wise-pattern reconstruction are two such techniques.

Purpose of the Study:

  • To compare the short-term oncological and aesthetic outcomes of the Grisotti flap versus Wise-pattern reconstruction for central breast tumors.
  • To evaluate surgical margin status, postoperative complications, and patient/surgeon satisfaction.

Main Methods:

  • A randomized controlled trial involving 40 patients with central breast cancer.
  • Patients were randomized to either the Grisotti technique (n=20) or the Wise-pattern technique (n=20).
  • Outcomes assessed included surgical margins, complications, and aesthetic satisfaction over a mean follow-up of 6.9 months.

Main Results:

  • Both techniques achieved high rates of negative surgical margins (90% Grisotti, 100% Wise-pattern).
  • Postoperative complications were similar between groups, with seroma being the most common.
  • Patient satisfaction was high for both (85% Grisotti, 90% Wise-pattern), with no significant difference in surgeon satisfaction.

Conclusions:

  • The Grisotti and Wise-pattern techniques provide comparable short-term oncological safety and aesthetic outcomes for central breast tumors.
  • Individualized selection based on breast volume and ptosis is recommended.
  • Larger studies with longer follow-up are needed to assess long-term results.