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Reduced but Reversible Brain Entropy After Occupational Partial Sleep Deprivation in Night-Shift Medical Staff
Siqi Cai1, Fan Yang1,2, Chunxiang Jiang1
1Paul. C. Lauterbur Research Centers for Biomedical Imaging, State Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Brain and Behavior
|June 19, 2026
Summary
Partial sleep deprivation (PSD) in night-shift workers (NSW) reduces brain entropy (BEN), but this effect is largely reversible. Brain entropy metrics can identify individuals susceptible to PSD, aiding in optimizing shift schedules.
Area of Science:
- Neuroscience
- Sleep Medicine
- Medical Imaging
Background:
- Partial sleep deprivation (PSD) poses health risks to night-shift workers (NSW).
- The impact of PSD on local brain function is underexplored.
- Brain entropy (BEN) quantifies temporal irregularity in brain activity and may reveal dysfunction after sleep loss.
Purpose of the Study:
- To investigate the effects of acute PSD on brain entropy in NSWs.
- To explore the reversibility of PSD-induced BEN changes after recovery sleep.
- To develop a predictive model for identifying PSD-vulnerable individuals.
Main Methods:
- Seventy-eight female NSWs and 30 healthy controls (HC) underwent psychomotor vigilance tasks (PVT) and resting-state fMRI (rs-fMRI).
- Static and dynamic sample entropy (SampEn) were calculated for BEN.
- An L1-regularized logistic regression (LR) model used baseline SampEn to differentiate PSD-vulnerable and PSD-resistant individuals.
Main Results:
- Acute PSD in NSWs significantly altered both static and dynamic SampEn metrics.
- These alterations were largely reversible after 3-5 days of regular sleep.
- The SampEn-based LR model achieved 78.26% accuracy in distinguishing PSD-vulnerable from PSD-resistant individuals.
Conclusions:
- One night of acute PSD reduces BEN, but this is mostly reversible.
- Chronic PSD may lead to sustained BEN reduction in specific brain regions, correlating with poor sleep quality.
- BEN metrics show potential as biomarkers for identifying individual susceptibility to PSD and optimizing shift work schedules.
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